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A significant reduction in CD4+ cells is associatedwith several immunodeficient states (e.g., in patients withAIDS, undergoing radiotherapy or chemotherapy), implyingthat diminished CD4+ is indicative of impaired antibody pro-duction. Rothkamm K, Kruger I, Thompson LH, Lobrich M (2003) Pathways of DNA double-strandbreak repair during the mammalian cell cycle

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